Khwai is a village on the north bank of the Khwai River in the North-West District of Botswana. The river is the northern boundary of the Moremi Game Reserve, and the village is just outside the north gate of the reserve, which is on the eastern side of the Okavango Delta.

The village has a population of approximately 400 BaBukakhwe or River Bushmen. Most of the inhabitants are Babukakhwae but some are Bayei as well. The Babukakhwae are a section of the Basarwa, bushmen, or San. Bukakhwaedam is the ancestral language of this village, but Setswana, English, and Afrikaans are also heard.
The people of Khwai are developing an eco-tourism and sustainable development program to conserve the area's unique environment. They are building a community run safari organization as part of Botswana's community based natural resource management program. Numerous lodges and safari camps surround the village.